I'd have to go with either Serial Experiments: Lain (like, it's 16 episodes of WTF???) After like, episode 3, it gets really good, but the first few make you feel like shooting yourself in the face lol. After that I would most have to say Sayonara! Zetsubou Sensei. It's Azumanga on crack and acid, and is suicidal >>; it's pretty epic though >w<