Trust me when I say you don't need to worry about registration. Most people don't wait more than 15 to 30 minutes for their registration--and that's when the line is long. Our registration team has this stuff down to a science and it's been years since we've had complaints about long wait times for registration.
Exodia mentioned the old hotel--you may hear an occasional horror story about registration at the old hotel, like the Great Line of '04. Not only was the hotel unsuitable for as many people as we had, but a new team has taken over registration since then and they've done a marvelous job of processing thousands of people every weekend.
Long story short, you don't need to worry. If you want to bypass the lines, though, registration opens around 2:00 PM on Friday. Get there sometime around then. Most people arrive later in the afternoon or early in the evening (most con stuff doesn't start until about 5:00 PM on Friday) so that's when the lines are the longest. Get there sooner and you'll beat the rush. Then enjoy some time to relax, get situated in your hotel room, and explore the hotel a bit... get acquainted with the room locations and hotel layout.